全文获取类型
收费全文 | 102256篇 |
免费 | 10445篇 |
国内免费 | 4922篇 |
专业分类
耳鼻咽喉 | 867篇 |
儿科学 | 1876篇 |
妇产科学 | 1645篇 |
基础医学 | 13407篇 |
口腔科学 | 4591篇 |
临床医学 | 10554篇 |
内科学 | 15385篇 |
皮肤病学 | 1188篇 |
神经病学 | 10482篇 |
特种医学 | 2612篇 |
外国民族医学 | 9篇 |
外科学 | 10867篇 |
综合类 | 14404篇 |
现状与发展 | 22篇 |
一般理论 | 1篇 |
预防医学 | 11674篇 |
眼科学 | 1898篇 |
药学 | 7928篇 |
55篇 | |
中国医学 | 2906篇 |
肿瘤学 | 5252篇 |
出版年
2024年 | 140篇 |
2023年 | 1778篇 |
2022年 | 2791篇 |
2021年 | 4544篇 |
2020年 | 4623篇 |
2019年 | 3681篇 |
2018年 | 3759篇 |
2017年 | 3886篇 |
2016年 | 4236篇 |
2015年 | 3935篇 |
2014年 | 7216篇 |
2013年 | 8261篇 |
2012年 | 6673篇 |
2011年 | 6968篇 |
2010年 | 5619篇 |
2009年 | 4988篇 |
2008年 | 4905篇 |
2007年 | 4830篇 |
2006年 | 4317篇 |
2005年 | 3696篇 |
2004年 | 3186篇 |
2003年 | 2884篇 |
2002年 | 2402篇 |
2001年 | 2079篇 |
2000年 | 1692篇 |
1999年 | 1432篇 |
1998年 | 1286篇 |
1997年 | 1241篇 |
1996年 | 970篇 |
1995年 | 1028篇 |
1994年 | 946篇 |
1993年 | 794篇 |
1992年 | 790篇 |
1991年 | 774篇 |
1990年 | 627篇 |
1989年 | 558篇 |
1988年 | 479篇 |
1987年 | 423篇 |
1986年 | 362篇 |
1985年 | 469篇 |
1984年 | 404篇 |
1983年 | 240篇 |
1982年 | 323篇 |
1981年 | 287篇 |
1980年 | 233篇 |
1979年 | 196篇 |
1978年 | 171篇 |
1977年 | 147篇 |
1976年 | 153篇 |
1975年 | 66篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
61.
62.
63.
64.
Familial risk and heritability of intellectual disability: a population-based cohort study in Sweden
66.
Platelets have diverse roles in immune processes in addition to their key functions in haemostasis and thrombosis. Some studies imply that platelets may be possibly related to the immune tolerance induction. However, the role of platelets in the development of immune tolerance is not fully understood. The purpose of this study was to investigate the role of platelets in the development of regulatory mechanisms responsible for cutaneous inflammation using a mouse model of low zone tolerance (LZT). Mice were treated with 2,4,6‐trinitro‐1‐chlorobenzene (TNCB) 8 times every other day for tolerance induction with administration of anti‐platelet antibody or control antibody during the tolerance induction phase every 3 days. After the treatment for the tolerance induction, mice were sensitized and then challenged with TNCB. The contact hypersensitivity (CHS) was significantly decreased at 24 hours after challenge in the mice with LZT than in those without LZT. Platelet depletion via administration of anti‐platelet antibody reversed the inhibition of CHS and reduced the frequency of Foxp3+ Tregs in the inflamed skin and draining lymph nodes in mice with LZT. In addition, repeated low‐dose skin exposure resulted in elevated plasma levels of transforming growth factor (TGF)‐β1. Interestingly, platelet depletion reduced plasma TGF‐β1 levels of mice with LZT. Furthermore, the CHS response was reduced by administration of recombinant TGF‐β1 during platelet depletion in mice with LZT. Administration of anti‐TGF‐β antibody reversed the inhibition of the CHS responses. These results suggest that platelets are involved in the induction of immune tolerance via the release of TGF‐β1. 相似文献
67.
68.
Tryntsje Fokkema Robert Burggraaff Fred Hartgens Bas Kluitenberg Evert Verhagen Frank J.G. Backx Henk van der Worp Sita M.A. Bierma-Zeinstra Bart W. Koes Marienke van Middelkoop 《Journal of Science and Medicine in Sport》2019,22(3):259-263
Objectives
To investigate the prognosis and possible prognostic factors of running-related injuries (RRIs) in novice runners.Design
Prospective cohort study.Methods
Participants of Start to Run, a 6-weeks course for novice runners in The Netherlands, were asked to participate in this study. Before the start of the course a baseline questionnaire, on demographics, physical activity and perceived health, was sent to runners willing to participate. The 26- or 52-weeks follow-up questionnaires assessed information on RRIs and their duration. Only participants that sustained a RRI during follow-up were included in the analyses. An injury duration of 10 weeks or shorter was regarded as a relatively good prognosis, while an injury duration of more than 10 weeks was defined as a poor prognosis. To determine the associations between baseline characteristics and injury prognosis and between injury location and injury prognosis, multivariable logistic regression analyses were performed.Results
347 participants (48.8%) sustained an RRI during follow-up. The RRIs had an overall median duration of eight weeks (range: 1–52 weeks). Participants with a previous RRI were more likely to have a poor prognosis (OR 2.31; 95%CI 1.12–4.79), while a calf injury showed a trend towards an association with a relatively good prognosis (OR 0.49; 95%CI 0.22–1.11).Conclusions
The duration of RRIs in novice runners is relatively long, with only calf injuries being associated with a good prognosis. This emphasizes the need of injury prevention measures in novice runners and adequate support during and after an RRI, especially in runners with a previous injury. 相似文献69.
《Journal of bodywork and movement therapies》2019,23(3):452-455
BackgroundInspiratory muscle training (IMT) is an important method of attenuating both respiratory and peripheral effort perceptions, consequently improving neuromuscular performance and resulting in greater improvements in exercise capacity than exercise training alone.ObjectiveThe aim of this study was to investigate the effects of IMT on exercise tolerance, repeated sprint ability (RSA) performance, maximal inspiratory pressure (MIP), and peak inspiratory flow (PIF) in a cohort of professional male soccer players.MethodsTwenty-two healthy male professional soccer players (18.3 ± 1.4 years; 174.5 ± 6.1 cm; 70.5 kg ± 4.6 kg; body fat 10.1 ± 4.2%) from a club in the Brazilian first division soccer league participated in this study. IMT consisted of 15 and 30 self-paced inspiratory breaths (each to 50% maximal static inspiratory pressure [P0]) in the 1-and 2-week intervention period, respectively. IMT was performed prior to soccer training (1 sets.d−1; 6 d.wk−1) with repeated sprint ability (RSA) assessed pre- and post- the 2-week period of IMT.ResultsStatistical analyses identified a significant (p < 0.001) decrease in sprint time post-IMT. Additionally, RSAbest, RSAmean, total sprint time and percentage of RSA performance decrement (RSA % dec) also showed significant decreases (p < 0.0001) post-IMT. Additional measures including MIP and PIF were also significantly elevated (p < 0.0002) following the 2-week period of IMT.ConclusionIn conclusion, our results raise two important issues. Firstly, IMT demonstrated enhanced inspiratory muscle strength in professional soccer players. Secondly, this increase in inspiratory muscle efficiency led to a decrease in sprint time and improved exercise tolerance. We recommend that a standard training protocol be developed and tested in an experimental and control group with a large representative sample. 相似文献
70.